Long noncoding RNA ZFAS1 suppresses chondrocytes apoptosis via miR-302d-3p/SMAD2 in osteoarthritis

ABSTRACT Osteoarthritis (OA) seriously affects people's quality of life due to joint pain, stiffness, disability, and dyskinesia worldwide. Long noncoding RNA zinc finger antisense 1 (ZFAS1) is downregulated tightly associated with proliferation, migration, apoptosis, matrix synthesis chondrocyte in OA. However, the molecular mechanisms ZFAS1 OA remain unknown. The expression correlation between ZFAS1, miR-302d-3p, SMAD2 tissues was analyzed by Pearson analysis. a lower expression, expedited proliferation repressed apoptosis chondrocytes. MiR-302d-3p direct target ZFAS1. hindered facilitated partially reversed effect on positively regulated ZFAS1/miR-302d-3p. MiR-302d-3p-mediated were partly abrogated targeting SMAD2. promoted chondrocytes possibly regulating miR-302d-3p/SMAD2 axis, providing potential for treatment.